Prostate cancer is one of the most important cancers in men. With a worldwide incidence of 25.3 per 100,000 it is the second most common cancer in men, with large differences between countries. Important clues on risk factors remain to be found. Age, genetic factors and environmental influences have been studied. Incidence has been increasing over the last few decades, largely due to early detection procedures. The mortality rate of 8.1 per 100,000 mainly affects men at older ages; increases in this rate over time and differences between countries are markedly smaller than for incidence. For the future, prostate cancer will remain an important and—through evolutions in incidence and demography—growing health problem.
Origin Of Prostate Cancer :
The stem (basal) cells of prostate acini are considered the origin of prostate cancer. Between these cells and the final secretory cells, different intermediate or transit cells can be observed, and every one of them can evolve into malignant cells,explaining the biological variability of prostatic cancer.The exact changes between normal gland and prostatic intraepithelial neoplasia (PIN) are not yet known, but a post-inflammatory atrophy lesion is being studied in this respect. The PIN lesion is considered the pre-invasive change of prostatic cancer and its presence in needle biopsy is clinically used for follow-up of the patient. The progressive knowledge of the stromal invasion n prostate cancer (loss of some cell–cell adhesion molecules and expression of others) can be correlated with the Gleason grading system, and the molecular changes in the progression to androgen-independent carcinoma can be used as a prognostic marker in conjunction with the classical pathological markers.
Prostate Cancer – Causes , Symptoms , Treatment :
Prostate Cancer Is the Carcinoma of the Prostate gland Is Known as Prostate Cancer.
Causes Of Prostate Cancer : Causes of the Prostate Cancer are unknown , but the Origin of the Prostate Cancer can be associated with the Basal Cells of the Prostate Acini can be considered as the Origin of the Prostate Cancer .
Symptoms Of Prostate Cancer : The Early Symptoms are slightly seen or un seen In the Prostate Cancer which Thus Difficult to Diagnose the Prostate Cancer with out a Professional Help . The Swelling of Prostate Associated with the Tumor or the Cancer Spreading Beyond the Prostate Area the Symptoms may be Present Such as :
Frequent Urination During Night .
Weak Urinary Stream .
Difficulties Starting & Stopping the Urination .
Urine Leak while the abdominal Muscles Contract (While coughing , laughing , shouting).
Pain During Urination .
Pain During Ejaculation .
Reddish Blood or Blood in Urine/Seman.